Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency

Question  Does therapy with oral iron improve exercise capacity in patients with heart failure and iron deficiency?

Findings  In this randomized clinical trial of 225 adults with heart failure and reduced ejection fraction, oral iron polysaccharide minimally repleted iron stores and had no significant effect on exercise capacity at 16 weeks compared with placebo (+23 mL/min for oral iron polysaccharide vs −2 mL/min for placebo).

Meaning  These findings do not support the use of oral iron supplementation in patients with heart failure and reduced left ventricular ejection fraction and iron deficiency.

Reference: JAMA. 2017;317(19):1958-1966.

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